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That gap between expectation and physiology is precisely where protocols fail, not because the biology did nothing but because expectations were never set

However, the barriers to oral drug delivery (such as the solubility and dissolution, absorption, presystemic metabolism, and excretion) cannot be ignored too

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At the same time, there was an increasing focus on the potentially harmful effects of lipid peroxidation (Heath and Packer 1968), growing awareness that optimal activities of photosynthetic enzymes required a highly reducing environment (Wolosiuk and Buchanan 1977

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